MUC5AChypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer

Microsatellite instability in colitis associated colorectal cancer.

Microsatellite instability in colitis associated colorectal cancer

Microsatellite instability in colitis associated colorectal cancer As molecular pathways of colon carcinogenesis continue to be defined for high risk hereditary colon cancer syndromes and for average risk sporadic colon cancers, it seems that colon carcinogenesis in the setting of chronic idiopathic inflammatory bowel disease (IBD) may be unique. 1 Although to some extent this notion seems intu...

Microsatellite instability in colitis associated colorectal cancer

Microsatellite instability in colitis associated colorectal cancer As molecular pathways of colon carcinogenesis continue to be defined for high risk hereditary colon cancer syndromes and for average risk sporadic colon cancers, it seems that colon carcinogenesis in the setting of chronic idiopathic inflammatory bowel disease (IBD) may be unique. 1 Although to some extent this notion seems intu...

[Microsatellite instability among patients with colorectal cancer].

BACKGROUND In patients with colorectal carcinoma, insertions or deletions of short sequences of DNA, a phenomenon called microsatellite instability, are observed. AIM To look for microsatellite instability and mutations of MLH1 and MSH2 gene mutations in patients with colorectal carcinoma. MATERIAL AND METHODS Ten patients with sporadic colorectal carcinoma and 31 patients fulfilling criter...

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA-mismatch-repair system deficiency because of a germline/somatic mutation in mismatch-repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic C...